On 6 July 1829 he married Julia, the second daughter of Minchin Lucas of Dublin; Julia was born on 16 October 1809. In 1832 he was Secretary to The Jersey Board of Health and played a prominent part in combatting the Asiatic cholera plague in the Island. As a result, the Island presented him with a magnificent silver cup. The inscriptions are notable for the different script styles utilised on each line.
He bought 38 New Street, St Helier in June 1832 and sold it in May 1864. He then bought land in St Saviour in August 1851 and built Glenville, where he lived until he sold that in 1870. Finally he bought 19 Midvale Road in July 1873 from a Miss Ryder for £850, and lived there until he died on 28 May 1879, just after his son Lucas George was married. His obituary was noted in the local press:
- “We are also sorry to have to announce the death of Dr George Symes Hooper who was very well known on the island. The deceased who had been ailing for some time past died rather suddenly yesterday at the advanced age of 79.”